Week 15 TNF 49ers vs. Rams Start ‘Em Sit ‘Em Picks feat. Kyren Williams, Puka Nacua, Deebo Samuel

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Week 15 49ers vs Rams TNF Fantasy Football Start ‘Em picks Week 15 49ers vs Rams TNF Fantasy Football Sit ‘Em picks

Week 15 of the 2024 fantasy football season kicks off with a Thursday Night Football showdown between the Los Angeles Rams and San Francisco 49ers. This is an important NFC West matchup with playoff implications featuring two teams with high-powered offenses. Here are some of the best targets and fades for fantasy lineups this week.

Week 15 49ers vs Rams TNF Fantasy Football Start ‘Em picks

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Kyren Williams is having an incredibly consistent 2024 fantasy football season, finishing as the RB27 or better in all 13 of his games so far. He has also finished among the top ten weekly running backs four times, including each of the past two weeks, leading to his current overall ranking as the RB7 this year. He makes for an elite lineup option this week against the San Francisco 49ers, despite facing a strong defense.

Puka Nacua has finished among the top 20 weekly wide receivers in six of his seven games since making his return to the Los Angeles Rams after suffering an injury. He is also coming off his best game of the year, setting season-highs with 17 touches on 19 targets for 178 scrimmage yards and two total touchdowns against the Buffalo Bills. His consistent output and positive momentum make him one of the best overall wide receivers for lineups this week.

Must Starts

Kyren Williams
Puka Nacua
Cooper Kupp
George Kittle

DFS Picks

Brock Purdy
Matthew Stafford
Jauan Jennings

Week 15 49ers vs Rams TNF Fantasy Football Sit ‘Em picks

Deebo Samuel has been uncharacteristically unproductive in fantasy football recently. He has failed to exceed 25 receiving yards in each of his past four games and has been held without a touchdown for eight consecutive weeks. The 49ers have been utilizing their other offensive weapons much more than Samuel, making him a clear fade in Week 15 lineups, especially with the fantasy playoffs kicking off this week in most leagues.

He is joined by Blake Corum, who has yet to establish a large enough role with the Rams to provide much fantasy value. The rookie received eight carries in each of his past two games, matching his season-high, but he still hasn’t finished inside the top 40 running backs in any of his games so far. He simply can’t be trusted in fantasy lineups unless his role increases down the stretch.